Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233113 | 0.83 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL7034982 | 0.78 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL10959895 | 0.78 | NPSR1 (0.50) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL6626142 | 0.76 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL10691887 | 0.76 | ALDH1A1 (0.43) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL8820687 | 0.75 | ELANE (0.41) | KMT2ASMN1; SMN2AKT1ALDH1A1TSHR | |
| SCHEMBL2189058 | 0.75 | KMT2A (0.59) | KMT2AMEN1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL11437979 | 0.75 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL9435677 | 0.75 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL4227731 | 0.74 | ALDH1A1 (0.63) | KMT2ASMN1; SMN2CDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859007-A | TREATMENT OF DIABETES, OBESITY | GLAXO WELLCOME INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |