Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PPARD | Q03181 | 7/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096425 | 0.96 | CES2 (0.54) | CES2CES1PTGS2 | |
| SCHEMBL32074 | 0.96 | CES2 (0.54) | CES2CES1PTGS2 | |
| SCHEMBL3084634 | 0.96 | CES2 (0.54) | CES2CES1PTGS2 | |
| SCHEMBL8092296 | 0.94 | CES2 (0.53) | CES2CES1PTGS2ESR1 | |
| SCHEMBL5178120 | 0.90 | PTGS2 (0.57) | CES2CES1PTGS2ALDH1A1ESR1 | |
| SCHEMBL29717021 | 0.87 | CES2 (0.46) | CES2CES1PTGS2 | |
| SCHEMBL7527911 | 0.87 | CES2 (0.46) | CES2CES1PTGS2 | |
| Octanoic Acid SCHEMBL3647827 | 0.86 | CES2 (0.50) | CES2CES1HDAC11HDAC3HDAC4 | |
| SCHEMBL31697573 | 0.85 | CES2 (0.44) | CES2CES1PTGS2 | |
| SCHEMBL38663795 | 0.85 | TDP1 (0.50) | CES2CES1PTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5976555-A | EMULSIFIER SYSTEM | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1999-11-02 | — | — | US | disclosed |