Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967339 | 0.90 | KMT2A (0.41) | KMT2APOLBMEN1FAAHMAPK1 | |
| SCHEMBL1968575 | 0.83 | RXFP1 (0.39) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL2775866 | 0.83 | RXFP1 (0.39) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL2830973 | 0.83 | ACACB (0.39) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL9756348 | 0.81 | FAAH (0.46) | KMT2AMEN1FAAHMAPK1NOD1 | |
| SCHEMBL7601775 | 0.81 | ALDH1A1 (0.39) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL4955377 | 0.79 | TSHR (0.38) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL2824469 | 0.79 | TSHR (0.38) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL1564967 | 0.78 | SOAT1 (0.41) | KMT2APOLBMEN1TSHRALDH1A1 | |
| SCHEMBL1194168 | 0.78 | SOAT1 (0.41) | KMT2APOLBMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5599830-A | ANGIOTENSIN INHIBITORS | ROUSSEL UCLAF (FR) | 1997-02-04 | — | — | US | disclosed |
| US-5482957-A | Azole derivatives, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-01-09 | — | — | US | disclosed |
| US-5470867-A | Imidazoles and their salts having antagonistic activity to angiotesin II recetors | ROUSSEL-UCLAF (FR) | 1995-11-28 | — | — | US | disclosed |
| US-5440046-A | Angiotensin antagonist, hypotensive agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| US-5412101-A | Angiotensin II inhibitor | ROUSSEL-UCLAF (FR) | 1995-05-02 | — | — | US | disclosed |
| US-5389634-A | Treating arterial hypertension, relaxing uterus, prevention of post-angioplastic restenosis | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5350751-A | Hypotensive agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-09-27 | — | — | US | disclosed |
| US-5338756-A | Angiotensin II receptor antagonists | ROUSSEL UCLAF (FR) | 1994-08-16 | — | — | US | disclosed |
| US-5225414-A | SUBSTITUTED AZOLES, A PROCESS FOR THEIR PREPARATION, AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-06 | — | — | US | disclosed |