Sugi Predict

Sugi Predict / Compounds / SCHEMBL1968575

SCHEMBL1968575

SCHEMBL1968575

CCOC(=O)C(C#N)NC(=O)CC

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 1/20 0.39
▸ CYP2C9 P11712 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ ALDH1A1 P00352 4/20 0.36
▸ TSHR P16473 1/20 0.36
▸ KMT2A Q03164 4/20 0.36
▸ POLB P06746 1/20 0.36
▸ GAA P10253 3/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ MGAM O43451 1/20 0.35
▸ SI P14410 1/20 0.35
▸ MGAM2 Q2M2H8 1/20 0.35
▸ SOAT1 P35610 1/20 0.35
▸ HTT P42858 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ CAD P27708 1/20 0.34
▸ ACACB O00763 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2775866 1.00 RXFP1 (0.39) RXFP1CYP2C9L3MBTL1ALDH1A1TSHR
SCHEMBL7601775 0.86 ALDH1A1 (0.39) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL1967339 0.86 KMT2A (0.41) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL4955377 0.84 TSHR (0.38) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL2824469 0.84 TSHR (0.38) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL1194168 0.83 SOAT1 (0.41) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL1564967 0.83 SOAT1 (0.41) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL8431191 0.83 KMT2A (0.45) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL2830973 0.82 ACACB (0.39) L3MBTL1ALDH1A1TSHRKMT2APOLB
SCHEMBL2829956 0.80 APOBEC3G (0.43) L3MBTL1ALDH1A1TSHRKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3965803-B1 SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS DANA FARBER CANCER INST INC (US) 2025-08-20 — — EP disclosed
US-12365696-B2 Small-molecule focal adhesion kinase (FAK) inhibitors DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-07-22 — — US disclosed
US-20220242882-A1 SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-08-04 — — US disclosed
EP-3965803-A1 SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS Dana-Farber Cancer Institute, Inc. (US) 2022-03-16 — — EP disclosed
CN-113811324-A Small molecule Focal Adhesion Kinase (FAK) inhibitors 达纳-法伯癌症研究公司 2021-12-17 — — CN disclosed
WO-2020231726-A1 SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-11-19 — — WO disclosed
US-20170035766-A1 IRAK INHIBITORS AND USES THEREOF NIMBUS IRIS INC (US) 2017-02-09 — — US disclosed
US-20170035766-A1 IRAK INHIBITORS AND USES THEREOF NIMBUS IRIS INC (US) 2017-02-09 — — US disclosed
US-9518065-B2 IRAK inhibitors and uses thereof NIMBUS IRIS, INC. (US) 2016-12-13 — — US disclosed
US-9518065-B2 IRAK inhibitors and uses thereof NIMBUS IRIS, INC. (US) 2016-12-13 — — US disclosed
EP-1844044-B1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2010-07-21 — — EP disclosed
US-7678815-B2 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. (US) 2010-03-16 — — US disclosed
WO-2010027236-A2 FUSED HETEROCYCLIC COMPOUND LG LIFE SCIENCES LTD. (KR) 2010-03-11 — — WO disclosed
WO-2010027236-A2 FUSED HETEROCYCLIC COMPOUND LG LIFE SCIENCES LTD. (KR) 2010-03-11 — — WO disclosed
US-20080312291-A1 Heterocyclic Gaba-b Modulators ASTRAZENECA AB (SE) 2008-12-18 — — US disclosed
US-20080312291-A1 Heterocyclic Gaba-b Modulators ASTRAZENECA AB (SE) 2008-12-18 — — US disclosed
WO-2007073296-A1 HETEROCYCLIC GABA-B MODULATORS ASTRAZENECA AB (SE) 2007-06-28 — — WO disclosed
US-20060160857-A1 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. 2006-07-20 — — US disclosed
US-5604251-A Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors HOECHST AKTIENGESELLSCHAFT (DE) 1997-02-18 — — US disclosed
US-4380641-A Insecticidal oxazolyl ureas ELI LILLY AND COMPANY (US) 1983-04-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12365696-B2 Small-molecule focal adhesion kinase (FAK) inhibitors PTK2, CTTN, TNK2 RXFP1 4169/4885CYP2C9 4863/4885L3MBTL1 3491/4885
US-20060160857-A1 Thiazole-4-carboxyamide derivatives GRM1, GRM2, GRIA4 RXFP1 177/4885CYP2C9 2618/4885L3MBTL1 2724/4885
US-20170035766-A1 IRAK INHIBITORS AND USES THEREOF IRAK2, IRAK3, IRAK1 RXFP1 3776/4885CYP2C9 4697/4885L3MBTL1 549/4885
US-20220242882-A1 SMALL-MOLECULE FOCAL ADHESION KINASE (FAK) INHIBITORS PTK2, CTTN, TNK2 RXFP1 4169/4885CYP2C9 4863/4885L3MBTL1 3491/4885
US-20080312291-A1 Heterocyclic Gaba-b Modulators GABBR1, GABBR2, GABRB1 RXFP1 125/4885CYP2C9 659/4885L3MBTL1 3068/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.