Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429105 | 0.79 | PLAU (0.38) | NPC1MAPTSMN1; SMN2PLAURAB9A | |
| SCHEMBL8432291 | 0.72 | RXFP1 (0.40) | NPC1MAPK1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL8429236 | 0.71 | PLAU (0.36) | MAPK1MAPTSMN1; SMN2PLAURAB9A | |
| SCHEMBL8534255 | 0.70 | HTT (0.39) | NPC1MAPK1MAPTSMN1; SMN2PLAU | |
| Bicarbonate SCHEMBL7469511 | 0.67 | MAPT (0.65) | MAPTSMN1; SMN2RAB9AHTTMEN1 | |
| SCHEMBL8429456 | 0.67 | RXFP1 (0.44) | L3MBTL1MAPTSMN1; SMN2RAB9AHTT | |
| SCHEMBL4028152 | 0.65 | MAPK1 (0.58) | MAPK1MEN1KMT2AF10LMNA | |
| SCHEMBL4714552 | 0.65 | PLAU (0.60) | NPC1MAPK1MAPTSMN1; SMN2PLAU | |
| SCHEMBL798763 | 0.65 | PPARA (0.42) | L3MBTL1NPC1MAPTRAB9AMEN1 | |
| Bicarbonate SCHEMBL8492631 | 0.65 | NPC1 (0.61) | L3MBTL1NPC1SMN1; SMN2PLAURAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |