Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | F13A1 | P00488 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | FURIN | P09958 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13017282 | 0.84 | HPGD (0.56) | ALDH1A1MAPK1HTTF13A1TGM2 | |
| SCHEMBL3425886 | 0.83 | ALDH1A1 (0.60) | PLAUALDH1A1MITFPOLBMAPK1 | |
| SCHEMBL4089354 | 0.83 | MITF (0.65) | PLAUALDH1A1MITFPOLBMAPK1 | |
| SCHEMBL1185724 | 0.81 | SIGMAR1 (0.62) | PLAUALDH1A1MITFPOLBMAPT | |
| SCHEMBL4028152 | 0.80 | MAPK1 (0.58) | MAPK1SIRT2F2F10LMNA | |
| SCHEMBL10712928 | 0.79 | SIGMAR1 (0.42) | PLAUALDH1A1F13A1TGM2RAB9A | |
| Methane SCHEMBL28113069 | 0.79 | SIGMAR1 (0.60) | PLAUALDH1A1MITFPOLBMAPT | |
| Bicarbonate SCHEMBL8492631 | 0.79 | NPC1 (0.61) | PLAUALDH1A1MITFPOLBRAB9A | |
| Bicarbonate SCHEMBL27820322 | 0.79 | NPC1 (0.61) | PLAUALDH1A1MITFPOLBRAB9A | |
| SCHEMBL6392968 | 0.79 | MITF (0.69) | PLAUALDH1A1MITFPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107311937-A | The licochalcone A dihydro amino-metadiazine compound and its synthetic method of one class tool antitumor activity | 陕西科技大学 | 2017-11-03 | — | — | CN | disclosed |
| EP-1373257-B9 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1373257-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-28 | — | — | EP | disclosed |
| US-6949544-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1373257-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20030087922-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-08 | — | — | US | disclosed |
| WO-2002079197-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087922-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | CDK2, LCK, CDK5 | PLAU 3784/4885ALDH1A1 4705/4885MITF 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.