Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429105 | 0.78 | PLAU (0.38) | PLAUHTTMAPTMEN1KMT2A | |
| SCHEMBL8534255 | 0.75 | HTT (0.39) | PLAUHTTMAPTMEN1KMT2A | |
| SCHEMBL8432256 | 0.71 | L3MBTL1 (0.38) | PLAUHTTMAPTMEN1KMT2A | |
| SCHEMBL8432291 | 0.68 | RXFP1 (0.40) | HTTMAPTKMT2ARAB9ALMNA | |
| Bicarbonate SCHEMBL7469511 | 0.68 | MAPT (0.65) | HTTMAPTMEN1KMT2ARAB9A | |
| SCHEMBL4714552 | 0.66 | PLAU (0.60) | PLAUHTTMAPTMEN1KMT2A | |
| Bicarbonate SCHEMBL8492631 | 0.65 | NPC1 (0.61) | PLAUMEN1KMT2ARAB9AALDH1A1 | |
| Bicarbonate SCHEMBL27820322 | 0.65 | NPC1 (0.61) | PLAUMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL16450915 | 0.64 | HDAC8 (0.53) | HTTMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1999954 | 0.64 | ALDH1A1 (0.61) | HTTMAPTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |