Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430960 | 0.78 | MAPT (0.35) | MAPTNPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL8432442 | 0.72 | HPGD (0.36) | MAPTNPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL8431423 | 0.69 | DHODH (0.34) | MAPTNPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL8431235 | 0.69 | RXFP1 (0.32) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8431494 | 0.68 | NPC1 (0.34) | MAPTNPC1HTTRAB9A | |
| SCHEMBL8432437 | 0.68 | RXFP1 (0.38) | MAPT | |
| SCHEMBL8429055 | 0.67 | TRPV4 (0.35) | MAPT | |
| SCHEMBL8432441 | 0.66 | KMT2A (0.32) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7456078 | 0.64 | ITGB3 (0.59) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL8431435 | 0.64 | CA1 (0.32) | MAPTNPC1HTTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |