Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 3/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495951 | 0.92 | EDNRA (0.46) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8524654 | 0.91 | SMN1; SMN2 (0.39) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8329557 | 0.89 | MEN1 (0.39) | EDNRASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL8431736 | 0.88 | BRS3 (0.42) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8431636 | 0.87 | ALDH1A1 (0.40) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8329904 | 0.87 | PPARG (0.38) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8431530 | 0.84 | EDNRA (0.37) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7506559 | 0.84 | BRS3 (0.40) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6579920 | 0.83 | EDNRA (0.46) | BRS3EDNRASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6582508 | 0.82 | EDNRA (0.43) | EDNRAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932741-A | TREATING ILLNESSES RESULTING FROM ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-08-03 | — | — | US | disclosed |
| US-5811444-A | IMIDAZOLE DERIVATIVES | ROUSSEL UCLAF (FR) | 1998-09-22 | — | — | US | disclosed |