Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.39 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8433463 | 1.00 | HRH1 (0.42) | HRH1HTR2AKDM4EL3MBTL1SLC6A2 | |
| SCHEMBL6587141 | 0.90 | HTR2A (0.50) | HRH1HTR2AKDM4ESLC6A2LMNA | |
| Maleic Acid SCHEMBL6589525 | 0.86 | SLC6A2 (0.42) | HTR2AKDM4EL3MBTL1SLC6A2LMNA | |
| Fumaric Acid SCHEMBL6589530 | 0.86 | SLC6A2 (0.42) | HTR2AKDM4EL3MBTL1SLC6A2LMNA | |
| Maleic Acid SCHEMBL6589717 | 0.84 | SLC6A2 (0.39) | HTR2AKDM4EL3MBTL1SLC6A2LMNA | |
| Fumaric Acid SCHEMBL6592830 | 0.84 | SLC6A2 (0.39) | HTR2AKDM4EL3MBTL1SLC6A2LMNA | |
| Fumaric Acid SCHEMBL6592056 | 0.81 | ESR1 (0.37) | SLC6A2LMNACYP3A4MEN1KMT2A | |
| Maleic Acid SCHEMBL6589825 | 0.81 | ESR1 (0.37) | SLC6A2LMNACYP3A4MEN1KMT2A | |
| Fumaric Acid SCHEMBL6587770 | 0.78 | LMNA (0.40) | KDM4EL3MBTL1SLC6A2LMNACYP3A4 | |
| Fumaric Acid SCHEMBL6587762 | 0.78 | LMNA (0.40) | KDM4EL3MBTL1SLC6A2LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874583-A | TREATING DEPRESSION, OBSESSIVE COMPULSIVE DISORDER, STUTTERING, TRICHOTILLOMANIA | HOECHST MARION ROUSSEL INC. (US) | 1999-02-23 | — | — | US | disclosed |