Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8435766 | 0.97 | MTNR1A (0.45) | MTNR1AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8435189 | 0.96 | MTNR1A (0.45) | MTNR1AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8436992 | 0.83 | MTNR1A (0.48) | MTNR1AKDM4EMCHR1HTR1AKCNH2 | |
| SCHEMBL8433692 | 0.80 | MTNR1A (0.49) | MTNR1AKDM4EMCHR1HTR1AKCNH2 | |
| SCHEMBL8432417 | 0.80 | MTNR1A (0.46) | MTNR1AMCHR1HTR1AKCNH2DRD3 | |
| SCHEMBL8432628 | 0.79 | MTNR1A (0.48) | MTNR1AKDM4EMCHR1HTR1AKCNH2 | |
| SCHEMBL8433667 | 0.79 | MTNR1A (0.56) | MTNR1AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8644533 | 0.77 | MTNR1A (0.46) | MTNR1AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8436332 | 0.77 | MTNR1A (0.48) | MTNR1AMCHR1HTR1AKCNH2DRD3 | |
| SCHEMBL8436770 | 0.76 | MTNR1A (0.51) | MTNR1AKDM4EMCHR1HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972964-A | FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION | H. LUNDBECK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| EP-0673360-B1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | LUNDBECK & CO AS H (DK) | 1998-08-26 | — | — | EP | disclosed |