Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 10/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.43 |
| ▸ | DRD2 | P14416 | 9/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432417 | 0.90 | MTNR1A (0.46) | MTNR1ADRD3KCNH2DRD2HTR1A | |
| SCHEMBL8436332 | 0.87 | MTNR1A (0.48) | MTNR1ADRD3KCNH2DRD2HTR1A | |
| SCHEMBL8433656 | 0.83 | MTNR1A (0.46) | MTNR1ADRD3KCNH2HTR1AMCHR1 | |
| SCHEMBL8435189 | 0.81 | MTNR1A (0.45) | MTNR1ADRD3KCNH2HTR1AMCHR1 | |
| SCHEMBL8435766 | 0.81 | MTNR1A (0.45) | MTNR1AKCNH2HTR1AMCHR1KDM4E | |
| SCHEMBL8433692 | 0.80 | MTNR1A (0.49) | MTNR1AKCNH2HTR1AMCHR1KDM4E | |
| SCHEMBL8432628 | 0.79 | MTNR1A (0.48) | MTNR1ADRD3KCNH2DRD2HTR1A | |
| SCHEMBL8641270 | 0.79 | MTNR1A (0.53) | MTNR1ADRD3DRD2MCHR1KDM4E | |
| SCHEMBL8436770 | 0.76 | MTNR1A (0.51) | MTNR1AKCNH2HTR1AMCHR1KDM4E | |
| SCHEMBL8433848 | 0.73 | MTNR1A (0.67) | MTNR1AMCHR1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972964-A | FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION | H. LUNDBECK A/S (DK) | 1999-10-26 | — | — | US | disclosed |
| EP-0673360-B1 | AMINOMETHYLINDANS, -BENZOFURANES AND -BENZOTHIOPHENES | LUNDBECK & CO AS H (DK) | 1998-08-26 | — | — | EP | disclosed |