Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436332 | 0.84 | MTNR1A (0.48) | MTNR1AMCHR1KCNH2MCHR2HTR1A | |
| SCHEMBL8436770 | 0.83 | MTNR1A (0.51) | MTNR1AMCHR1KCNH2MCHR2NQO2 | |
| SCHEMBL8436992 | 0.80 | MTNR1A (0.48) | MTNR1AMCHR1KCNH2HTR1AKDM4E | |
| SCHEMBL8433656 | 0.80 | MTNR1A (0.46) | MTNR1AMCHR1KCNH2HTR1AKDM4E | |
| SCHEMBL8435766 | 0.79 | MTNR1A (0.45) | MTNR1AMCHR1KCNH2HTR1AKDM4E | |
| SCHEMBL8435189 | 0.79 | MTNR1A (0.45) | MTNR1AMCHR1KCNH2NQO2HTR1A | |
| SCHEMBL8432417 | 0.78 | MTNR1A (0.46) | MTNR1AMCHR1KCNH2MCHR2HTR1A | |
| SCHEMBL8432628 | 0.78 | MTNR1A (0.48) | MTNR1AMCHR1KCNH2MCHR2NQO2 | |
| SCHEMBL8433848 | 0.77 | MTNR1A (0.67) | MTNR1AMCHR1NQO2KDM4EMAPT | |
| SCHEMBL8432639 | 0.73 | MTNR1A (0.62) | MTNR1ANQO2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972964-A | FOR TREATMENT OF CERTAIN PSYCHIC AND NEUROLOGIC DISORDERS SUCH AS PSYCHOSIS, ANXIETY DISORDERS, PANIC DISORDER, OBSESSIVE COMPULSIVE DISORDER, DEPRESSION, IMPULSE CONTROL DISORDERS, ALCOHOL ABUSE, AGGRESSION | H. LUNDBECK A/S (DK) | 1999-10-26 | — | — | US | disclosed |