Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8435684 | 0.99 | PTGS1 (0.30) | PTGS1PTGS2 | |
| SCHEMBL8433423 | 0.83 | TDP1 (0.45) | TSHRMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL8434788 | 0.82 | TDP1 (0.44) | TSHRMAPK1TDP1 | |
| SCHEMBL8438546 | 0.79 | SMN1; SMN2 (0.47) | TSHRMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL8437558 | 0.78 | SMN1; SMN2 (0.46) | TSHRMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL8495699 | 0.77 | RAB9A (0.43) | TSHRMAPK1TDP1 | |
| SCHEMBL8432986 | 0.76 | TAAR1 (0.46) | TSHRMAPK1TDP1 | |
| SCHEMBL8433601 | 0.75 | ALDH1A1 (0.35) | — | |
| Hydrochloric Acid SCHEMBL8435756 | 0.75 | TAAR1 (0.45) | TSHRMAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL8435335 | 0.74 | ALDH1A1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |