Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TPH1 | P17752 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8437558 | 0.99 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL8432986 | 0.87 | TAAR1 (0.46) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8435756 | 0.86 | TAAR1 (0.45) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL8433423 | 0.85 | TDP1 (0.45) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8434788 | 0.84 | TDP1 (0.44) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL8438754 | 0.80 | TSHR (0.49) | NPC1TDP1L3MBTL1MAPTKDM4E | |
| SCHEMBL8433690 | 0.79 | PTGS1 (0.31) | TDP1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL8437496 | 0.79 | TSHR (0.48) | NPC1TDP1L3MBTL1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8435684 | 0.78 | PTGS1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL8495699 | 0.77 | RAB9A (0.43) | SMN1; SMN2NPC1RAB9ATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |