Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.37 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30533678 | 1.00 | NNMT (0.41) | NNMTHDAC8MAPTTSHRHSD17B10 | |
| SCHEMBL546287 | 0.98 | NNMT (0.42) | NNMTHDAC8MAPTTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL28837202 | 0.96 | NNMT (0.41) | NNMTHDAC8MAPTTSHRHSD17B10 | |
| Iodide SCHEMBL29354004 | 0.96 | NNMT (0.41) | NNMTHDAC8MAPTTSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL11768005 | 0.81 | HDAC8 (0.41) | HDAC8MAPTTSHRL3MBTL1ACHE | |
| Hydrochloric Acid SCHEMBL150596 | 0.81 | HDAC8 (0.46) | HDAC8MAPTTSHRCYP2C19ACHE | |
| SCHEMBL13113036 | 0.78 | HDAC8 (0.43) | HDAC8MAPTTSHRACHEHRH1 | |
| SCHEMBL29922 | 0.78 | HDAC8 (0.48) | HDAC8MAPTTSHRACHEHRH1 | |
| SCHEMBL272532 | 0.77 | USP2 (0.42) | HDAC8MAPTTSHRTDP1L3MBTL1 | |
| SCHEMBL15822329 | 0.77 | HDAC8 (0.46) | HDAC8MAPTTSHRCYP2C19ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101102968-B | Improved dispenser for a tablet, and methods for use | RECKITT BENCKISER INC | 2010-10-06 | — | — | CN | disclosed |
| CN-101102968-A | Improved dispenser for a tablet, and methods for use | RECKITT BENCKISER INC (US) | 2008-01-09 | — | — | CN | disclosed |
| CN-1512871-A | Hair conditioning composition comprising cellulosic polymer | 宝洁公司 | 2004-07-14 | — | — | CN | disclosed |
| CN-1155686-C | Abrasive cleaning compositions | 雷克特本克斯尔(英国)有限公司 | 2004-06-30 | — | — | CN | disclosed |
| CN-1272132-A | Acidic, thickened cleaning and disinfecting compositions | RICKITT & BENKSIER (US) | 2000-11-01 | — | — | CN | disclosed |
| CN-1246889-A | Abrasive cleaning compositions | RECKITT & COLMANN PROD LTD (GB) | 2000-03-08 | — | — | CN | disclosed |
| CN-1239864-A | Aqueous disinfecting cleaning composition | RECKITT & COLMAN INC (US) | 1999-12-29 | — | — | CN | disclosed |
| US-6001625-A | ENHANCING ORGANOPHOSPHATE DETOXIFICATION BY HUMAN ACETYLCHOLINESTERASE, BUTRYLCHOLINESTERASE OR CARBOXYLESTERASE BY SUBSTITUTING HISTIDINE CLOSE TO ACTIVE SITE SERINE; PRETREATMENT DRUGS FOR MILITARY/AGRICULTURE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1999-12-14 | — | — | US | disclosed |
| CN-1106651-A | Kosmetic agent | HOECHST AG (DE) | 1995-08-16 | — | — | CN | disclosed |
| US-4105665-A | MONOMETHINE DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-08-08 | — | — | US | disclosed |
| US-4018796-A | FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-19 | — | — | US | disclosed |