Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922 | 0.98 | HDAC8 (0.48) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| SCHEMBL15822329 | 0.96 | HDAC8 (0.46) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| Bromide SCHEMBL142435 | 0.96 | HDAC8 (0.46) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| Acetic Acid SCHEMBL149422 | 0.92 | HDAC8 (0.43) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| Sulfuric Acid SCHEMBL143279 | 0.87 | HDAC8 (0.39) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| Sulfuric Acid SCHEMBL143278 | 0.87 | HDAC8 (0.39) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| P-Cresol SCHEMBL872802 | 0.84 | ACHE (0.43) | HDAC8SMN1; SMN2MAPTACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL11768005 | 0.83 | HDAC8 (0.41) | HDAC8SMN1; SMN2MAPTACHETSHR | |
| SCHEMBL144101 | 0.81 | CA12 (0.39) | HDAC8SMN1; SMN2MAPTTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL30533678 | 0.81 | NNMT (0.41) | HDAC8SMN1; SMN2MAPTACHETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315576-B1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO KGAA (DE) | 2013-12-25 | — | — | EP | claimed |
| US-8273332-B2 | Hair care product containing acetylpyridinium salts | HENKEL AG & CO. KGAA (DE) | 2012-09-25 | — | — | US | claimed |
| US-8246938-B2 | Hair care agent containing acetylpyridinium salts | HENKEL AG & CO. KGAA (DE) | 2012-08-21 | — | — | US | claimed |
| US-20120121528-A1 | Hair Care Agent Containing Acetylpyridinium Salts | HENKEL AG & CO. KGAA (DE) | 2012-05-17 | — | — | US | claimed |
| EP-2429483-A2 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | Henkel AG & Co. KGaA (DE) | 2012-03-21 | — | — | EP | claimed |
| EP-2429484-A2 | HAIR CARE AGENT CONTAINING ACETYLPYRIDINIUM SALTS | Henkel AG & Co. KGaA (DE) | 2012-03-21 | — | — | EP | claimed |
| US-20120058071-A1 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | GROSS WIBKE (DE) | 2012-03-08 | — | — | US | claimed |
| EP-2320854-B1 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | HENKEL AG & CO KGAA (DE) | 2012-01-18 | — | — | EP | claimed |
| US-8034122-B2 | Bleaching agent comprising 2-acylpyridinium derivatives | HENKEL AG & CO. KGAA (DE) | 2011-10-11 | — | — | US | claimed |
| US-8021438-B2 | Cationic acylpyridinium derivatives for use as bleach activators | HENKEL AG & CO. KGAA (DE) | 2011-09-20 | — | — | US | claimed |
| WO-2011082848-A2 | ANTIBACTERIAL AND BLEACHING ORAL AND DENTAL HYGIENE AND CLEANING AGENT II | HENKEL AG & CO. KGAA (DE) | 2011-07-14 | — | — | WO | claimed |
| US-20110162671-A1 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2011-07-07 | — | — | US | claimed |
| US-20110146006-A1 | CATIONIC ACYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2011-06-23 | — | — | US | claimed |
| EP-2320854-A2 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | Henkel AG & Co. KGaA (DE) | 2011-05-18 | — | — | EP | claimed |
| EP-2315576-A1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | Henkel AG & Co. KGaA (DE) | 2011-05-04 | — | — | EP | claimed |
| WO-2010130513-A2 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | HENKEL AG & CO. KGAA (DE) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130526-A2 | HAIR CARE AGENT CONTAINING ACETYLPYRIDINIUM SALTS | HENKEL AG & CO. KGAA (DE) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130510-A2 | HAIR SHAPING PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | HENKEL AG & CO. KGAA (DE) | 2010-11-18 | — | — | WO | claimed |
| WO-2010029006-A2 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2010-03-18 | — | — | WO | claimed |
| WO-2010022996-A1 | CATIONIC ACETYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | HENKEL AG & CO. KGAA (DE) | 2010-03-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110162671-A1 | BLEACHING AGENT COMPRISING 2-ACYLPYRIDINIUM DERIVATIVES | KRT18, CBR3, ACOX3 | ACHE 1430/4885HDAC8 554/4885SMN1; SMN2 3229/4885 |
| US-20120058071-A1 | HAIR CARE PRODUCT CONTAINING ACETYLPYRIDINIUM SALTS | KAT7, EP300, CUTA | ACHE 739/4885HDAC8 133/4885SMN1; SMN2 4509/4885 |
| US-20120121528-A1 | Hair Care Agent Containing Acetylpyridinium Salts | KAT7, EP300, HDAC7 | ACHE 811/4885HDAC8 35/4885SMN1; SMN2 4366/4885 |
| US-20110146006-A1 | CATIONIC ACYLPYRIDINIUM DERIVATIVES FOR USE AS BLEACH ACTIVATORS | KRT18, AADAC, KAT7 | ACHE 487/4885HDAC8 61/4885SMN1; SMN2 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.