Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TAS2R10 | Q9NYW0 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL8434094 | 0.95 | LMNA (0.59) | TSHRMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL9132260 | 0.93 | TSHR (0.50) | TSHRMEN1KMT2ALMNACYP2D6 | |
| Benzoic Acid SCHEMBL236709 | 0.92 | MEN1 (0.62) | TSHRMEN1KMT2ALMNACYP2D6 | |
| Terephthalic Acid SCHEMBL8434098 | 0.92 | ALDH1A1 (0.52) | TSHRMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL9137481 | 0.92 | MEN1 (0.49) | TSHRMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL9134307 | 0.91 | TSHR (0.48) | TSHRMEN1KMT2ALMNACYP2D6 | |
| Isophthalic Acid SCHEMBL8439194 | 0.87 | MEN1 (0.55) | TSHRMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL9131875 | 0.87 | KMT2A (0.52) | TSHRMEN1KMT2ALMNACYP2D6 | |
| SCHEMBL9134320 | 0.85 | LMNA (0.51) | TSHRMEN1KMT2ALMNACYP2D6 | |
| Tetrylammonium SCHEMBL8778011 | 0.85 | CA2 (0.57) | TSHRMEN1KMT2ALMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |