SCHEMBL8434129

SCHEMBL8434129

COCc1ccc(-c2ccc(COC)cc2COC)c(COC)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.42
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
CA2 P00918 1/20 0.37
TDP1 Q9NUW8 3/20 0.36
PRKCE Q02156 2/20 0.36
MYLK Q15746 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ALDH1A1 P00352 1/20 0.36
PRKCG P05129 1/20 0.36
MAPT P10636 1/20 0.36
PRKCA P17252 1/20 0.36
APEX1 P27695 1/20 0.36
RECQL P46063 1/20 0.36
MAOA P21397 1/20 0.35
DYRK1A Q13627 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.33
POLB P06746 1/20 0.33
FFAR1 O14842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8434092 0.88 PDK2 (0.39) PDK2LMNATP53CA2TDP1
SCHEMBL4965724 0.84 LMNA (0.40) PDK2LMNATP53CA2TDP1
SCHEMBL25446709 0.78 PRKCE (0.47) LMNATP53CA2TDP1PRKCE
SCHEMBL5936401 0.78 PTPN1 (0.39) PDK2LMNATP53CA2TDP1
SCHEMBL25446785 0.78 IDO1 (0.47) CA2ALDH1A1MAPTATM
SCHEMBL20897164 0.77 PDK2 (0.42) PDK2LMNATP53CA2MAOA
SCHEMBL9505730 0.76 LMNA (0.41) PDK2LMNATP53CA2TDP1
SCHEMBL10015634 0.76 LMNA (0.41) PDK2LMNATP53CA2TDP1
SCHEMBL134443 0.74 IDO1 (0.46) LMNATP53ERN1
SCHEMBL755548 0.74 PTPN1 (0.39) PDK2LMNATP53CA2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11071451-A None JP disclosed
JP-H1171451-A PHENOL NOVOLAC CONDENSATE MEIWA KASEI KK 1999-03-16 JP disclosed