SCHEMBL8434372

SCHEMBL8434372

Fc1ccc(CCC2CCC(C3CC[SiH](Cl)CC3)CC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.46
TAAR1 Q96RJ0 2/20 0.34
KCNH2 Q12809 1/20 0.34
DRD4 P21917 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8434369 1.00 MAOB (0.46) MAOBTAAR1KCNH2DRD4
SCHEMBL8434376 1.00 MAOB (0.46) MAOBTAAR1KCNH2DRD4
SCHEMBL8977283 0.91 MAOB (0.50) MAOBTAAR1KCNH2DRD4
SCHEMBL21581461 0.87 MAOB (0.55) MAOBTAAR1KCNH2
SCHEMBL8083840 0.86 MAOB (0.47) MAOBTAAR1
SCHEMBL8083843 0.86 MAOB (0.47) MAOBTAAR1
SCHEMBL7771491 0.86 MAOB (0.47) MAOBTAAR1
SCHEMBL21581462 0.85 MAOB (0.54) MAOBTAAR1KCNH2
SCHEMBL8436865 0.84 CNR1 (0.35) MAOB
SCHEMBL8436860 0.84 CNR1 (0.35) MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665232-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 1999-12-15 EP disclosed
US-5498737-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-03-12 US disclosed
EP-0665232-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-08-02 EP disclosed