Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAS2R10 | Q9NYW0 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL8434393 | 0.91 | ALPL (0.43) | CA4ALPLPOLBALPGCYP2D6 | |
| Cadaverine Tartrate SCHEMBL8438862 | 0.86 | ALPL (0.49) | ALPLPOLBALPGCYP2D6MEN1 | |
| Malic Acid SCHEMBL5875038 | 0.85 | KDM4E (0.52) | CA4ALPLPOLBALPGHDAC3 | |
| Bicarbonate SCHEMBL315104 | 0.82 | LMNA (0.50) | ALPLPOLBALPGCYP2D6MEN1 | |
| Bicarbonate SCHEMBL315102 | 0.82 | LMNA (0.50) | ALPLPOLBALPGCYP2D6MEN1 | |
| Cadaverine Tartrate SCHEMBL8438869 | 0.82 | ALPL (0.45) | ALPLPOLBALPGCYP2D6MEN1 | |
| Malonic Acid SCHEMBL3957244 | 0.81 | CYP2D6 (0.48) | ALPLPOLBALPGCYP2D6MEN1 | |
| Malonic Acid SCHEMBL3957236 | 0.81 | CYP2D6 (0.50) | ALPLPOLBALPGCYP2D6MEN1 | |
| Acetic Acid SCHEMBL306020 | 0.81 | LMNA (0.49) | ALPLPOLBALPGCYP2D6MEN1 | |
| Oxalic Acid SCHEMBL1050278 | 0.81 | LMNA (0.49) | ALPLPOLBALPGCYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5933693-A | Electroconductive elastic member and electrophotographic apparatus using same | BRIDGESTONE CORPORATION (JP) | 1999-08-03 | — | — | US | disclosed |