Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438573 | 0.85 | KMT2A (0.43) | TLR7AGTR1TLR8KMT2AAGTR2 | |
| SCHEMBL1256306 | 0.79 | TLR7 (0.56) | TLR7AGTR1TLR8AGTR2 | |
| SCHEMBL1258839 | 0.78 | TLR7 (0.53) | TLR7AGTR1TLR8AGTR2 | |
| SCHEMBL8793373 | 0.75 | AGTR1 (0.63) | AGTR1AGTR2 | |
| SCHEMBL9275378 | 0.75 | AGTR1 (0.78) | TLR7AGTR1AGTR2DRD2TBXA2R | |
| SCHEMBL7850660 | 0.75 | ALDH1A1 (0.64) | TLR7AGTR1KMT2AAGTR2MAPT | |
| SCHEMBL9235615 | 0.74 | TLR7 (0.54) | TLR7AGTR1TLR8AGTR2MAPT | |
| SCHEMBL3324054 | 0.74 | AGTR1 (0.59) | TLR7AGTR1AGTR2 | |
| SCHEMBL556 | 0.74 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL15331639 | 0.74 | TLR7 (0.54) | TLR7AGTR1TLR8AGTR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929249-A | ANGIOTENSIN II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-27 | — | — | US | disclosed |
| US-5728842-A | ANGIOTENSIN II RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |