Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434404 | 0.85 | TLR7 (0.52) | KMT2AMAPTAGTR1TLR7AGTR2 | |
| SCHEMBL8433990 | 0.74 | MEN1 (0.42) | KMT2AMAPTHTTPOLBTLR7 | |
| SCHEMBL8537440 | 0.73 | ALDH1A1 (0.44) | KMT2AMAPTHTTPOLBAGTR1 | |
| SCHEMBL4958333 | 0.72 | LMNA (0.73) | KMT2APOLBTLR7LMNAMEN1 | |
| SCHEMBL7156232 | 0.70 | ESR1 (0.54) | TLR7LMNATLR8MAPK1 | |
| SCHEMBL23507217 | 0.69 | VCAM1 (0.56) | KMT2AMAPTHTTAGTR1NPSR1 | |
| SCHEMBL8823613 | 0.67 | ALDH1A1 (0.44) | KMT2AMAPTAGTR1TLR7LMNA | |
| Hexane SCHEMBL28004600 | 0.66 | MGLL (0.63) | KMT2AMAPTLMNAMEN1SMN1; SMN2 | |
| SCHEMBL7998324 | 0.65 | VCAM1 (0.54) | KMT2AMAPTHTTLMNANPSR1 | |
| SCHEMBL1792416 | 0.65 | CYP4A11 (0.74) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929249-A | ANGIOTENSIN II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-27 | — | — | US | disclosed |
| US-5728842-A | ANGIOTENSIN II RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1994000120-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-01-06 | — | — | WO | disclosed |