Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.52 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613800 | 0.98 | CHEK2 (0.52) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL7838155 | 0.90 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL4143381 | 0.90 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL7418188 | 0.90 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL6609250 | 0.84 | CHEK2 (0.56) | CHEK2HRH2HRH1KDM4EALDH1A1 | |
| SCHEMBL7406714 | 0.84 | CHRNA7 (0.55) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL8440481 | 0.83 | CHRNB1 (0.45) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL8436877 | 0.83 | CHEK2 (0.51) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL611452 | 0.82 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3 | |
| SCHEMBL4317069 | 0.79 | CHEK2 (0.52) | CHEK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948793-A | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release | ABBOTT LABORATORIES (US) | 1999-09-07 | — | — | US | disclosed |
| US-5914328-A | CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS | ABBOTT LABORATORIES (US) | 1999-06-22 | — | — | US | disclosed |