Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.80 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | PTPRB | P23467 | 1/20 | 0.61 |
| ▸ | CDC25A | P30304 | 1/20 | 0.61 |
| ▸ | CDC25B | P30305 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70271 | 0.94 | KEAP1 (0.74) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Hydrochloric Acid SCHEMBL10982620 | 0.91 | KEAP1 (0.71) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| SCHEMBL12394493 | 0.89 | FFAR1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL235064 | 0.89 | KEAP1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL29619843 | 0.89 | KEAP1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL27523271 | 0.89 | KEAP1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL13618844 | 0.89 | KEAP1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL3419 | 0.89 | KEAP1 (1.00) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| Phenyl Propionic Acid SCHEMBL6660445 | 0.89 | KEAP1 (0.68) | FFAR1KEAP1HDAC3MAPK1ADRA1A | |
| SCHEMBL29615068 | 0.88 | KEAP1 (0.67) | FFAR1KEAP1HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998433-A | THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| CN-1160403-A | Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-09-24 | — | — | CN | disclosed |
| EP-0785939-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011201-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |