Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 12/20 | 0.63 |
| ▸ | PTPRB | P23467 | 1/20 | 0.54 |
| ▸ | CDC25A | P30304 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | PTEN | P60484 | 1/20 | 0.54 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31273986 | 0.96 | KEAP1 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL2016247 | 0.96 | KEAP1 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL8435278 | 0.89 | FFAR1 (0.80) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL70271 | 0.87 | KEAP1 (0.74) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL1666941 | 0.86 | SMN1; SMN2 (0.63) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL5264276 | 0.85 | KEAP1 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL5033023 | 0.85 | FFAR1 (0.65) | KEAP1FFAR1FFAR4 | |
| Hydrochloric Acid SCHEMBL10982620 | 0.85 | KEAP1 (0.71) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| Hydrochloric Acid SCHEMBL27491907 | 0.84 | SMN1; SMN2 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL19313223 | 0.84 | MAPT (0.62) | KEAP1HDAC3MAPK1ADRA1AHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401434-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002100403-A1 | MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS (PPAR) | ELI LILLY AND COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |