Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 3/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436325 | 0.90 | CYP2A6 (0.39) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL7342232 | 0.87 | GAA (0.38) | SMN1; SMN2ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL8438852 | 0.85 | CDC7 (0.36) | LMNAGSK3BRPS6KA3ALDH1A1HPGD | |
| SCHEMBL8436069 | 0.78 | TRPM8 (0.35) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL9004605 | 0.78 | IRAK4 (0.33) | LMNASMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL8435887 | 0.77 | LATS1 (0.38) | GSK3BLATS1LATS2BRAFCYP2A6 | |
| SCHEMBL8440253 | 0.75 | CHRM5 (0.38) | SMN1; SMN2GSK3BLATS1LATS2BRAF | |
| SCHEMBL8442574 | 0.75 | CYP2A6 (0.41) | LMNASMN1; SMN2GSK3BRPS6KA3ALDH1A1 | |
| SCHEMBL8436369 | 0.75 | SLC6A2 (0.37) | LATS1LATS2BRAFCYP2A6 | |
| SCHEMBL7335255 | 0.74 | CYP2A6 (0.38) | SMN1; SMN2ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856335-A | GLYCINE PARTIAL AGONISTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5519032-A | ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0581106-A1 | Substituted aminothienopyridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5252581-A | Modulators of neurotransmitters | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-10-12 | — | — | US | disclosed |