SCHEMBL8440253

SCHEMBL8440253

CN(c1ccncc1)c1csc2cnccc12

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM5 P08912 1/20 0.38
CHKA P35790 1/20 0.38
LATS1 O95835 8/20 0.36
LATS2 Q9NRM7 7/20 0.36
MAPT P10636 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP2A6 P11509 1/20 0.33
BRAF P15056 1/20 0.33
PTGS1 P23219 1/20 0.32
PTGS2 P35354 1/20 0.32
NPC1 O15118 1/20 0.32
GFER P55789 1/20 0.32
MAP3K7 O43318 3/20 0.32
TAB1 Q15750 3/20 0.32
NFATC1 O95644 1/20 0.31
GSK3B P49841 1/20 0.31
DYRK1A Q13627 1/20 0.31
KDM4C Q9H3R0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8440409 0.87 CYP2A6 (0.43) CHRM5CHKALATS1LATS2MAPT
SCHEMBL8039461 0.84 MAPT (0.39) CHRM5CHKAMAPTSMN1; SMN2CYP2A6
Hydrochloric Acid SCHEMBL8039050 0.83 MAPT (0.38) CHRM5CHKAMAPTSMN1; SMN2CYP2A6
SCHEMBL8435887 0.80 LATS1 (0.38) CHRM5CHKALATS1LATS2CYP2A6
SCHEMBL8051671 0.79 GRM1 (0.34) CHRM5CHKAMAPTSMN1; SMN2
SCHEMBL8054092 0.79 CHKA (0.44) CHRM5CHKAMAPTCYP2A6PTGS2
Hydrochloric Acid SCHEMBL8050418 0.78 CHKA (0.43) CHRM5CHKAMAPTCYP2A6
SCHEMBL8438852 0.78 CDC7 (0.36) LATS1CYP2A6BRAFMAP3K7TAB1
SCHEMBL8436369 0.78 SLC6A2 (0.37) LATS1LATS2CYP2A6BRAFMAP3K7
Hydrochloric Acid SCHEMBL8054021 0.78 GRM1 (0.34) CHRM5CHKAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5856335-A GLYCINE PARTIAL AGONISTS. HOECHST MARION ROUSSEL, INC. (US) 1999-01-05 US disclosed
EP-0581106-B1 Substituted aminothienopyridines, a process for their preparation and their use as medicaments HOECHST MARION ROUSSEL INC (US) 1998-05-20 EP disclosed
US-5519032-A ANTIDEPRESSANTS, ANXIOLYTICS, ANTIEMETICS, ANTIPSYCHOTIC HOECHST MARION ROUSSEL INC. (US) 1996-05-21 US disclosed
EP-0581106-A1 Substituted aminothienopyridines, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1994-02-02 EP disclosed
US-5252581-A Modulators of neurotransmitters HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1993-10-12 US disclosed