Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolopyrimidine SCHEMBL1703410 | 0.81 | RPS6KA3 (0.52) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL4570271 | 0.78 | PNP (0.47) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL9151696 | 0.67 | KDM4E (0.50) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL338384 | 0.65 | RPS6KA3 (0.52) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL8437718 | 0.65 | CXCR1 (0.45) | PNPCXCR2CXCR1AKR1B1 | |
| 8-Aminoguanine SCHEMBL21761 | 0.65 | PNP (1.00) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL8435570 | 0.63 | RPS6KA3 (0.49) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL6975489 | 0.63 | RPS6KA3 (0.49) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL8231702 | 0.62 | THRB (0.53) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL67181 | 0.61 | TLR7 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994321-A | Antiviral guanine analogs | ARONEX PHARMACEUTICALS, INC. (US) | 1999-11-30 | — | — | US | disclosed |
| US-5446045-A | Viricides for treating AIDS, viral diseases | TRIPLEX PHARMACEUTICAL CORPORATION | 1995-08-29 | — | — | US | disclosed |