Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolopyrimidine SCHEMBL1703410 | 0.81 | RPS6KA3 (0.52) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL8435574 | 0.78 | PNP (0.47) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL9151696 | 0.67 | KDM4E (0.50) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL8664722 | 0.65 | RPS6KA3 (0.61) | DYRK1AAURKADAPK3PRKD3MAP4K4 | |
| SCHEMBL20577 | 0.65 | PNP (0.73) | PNPTHRBMAPTKDM4EMEN1 | |
| SCHEMBL338384 | 0.65 | RPS6KA3 (0.52) | PNPDYRK1ATHRBMITFTP53 | |
| SCHEMBL8437718 | 0.65 | CXCR1 (0.45) | PNPDYRK1ACLK2CDK9LIMK1 | |
| 8-Aminoguanine SCHEMBL21761 | 0.65 | PNP (1.00) | PNPTHRBMITFTP53ALOX15 | |
| SCHEMBL13022826 | 0.63 | PNP (0.46) | PNPDYRK1ATHRBMITFTP53 | |
| SCHEMBL6975489 | 0.63 | RPS6KA3 (0.49) | PNPDYRK1ATHRBMITFTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9993491-B2 | Guanine riboswitch binding compounds and their use as antibiotics | SOCPRA—SCIENCES ET GÉNIE S.E.C. (CA) | 2018-06-12 | — | — | US | disclosed |
| US-9993491-B2 | Guanine riboswitch binding compounds and their use as antibiotics | SOCPRA—SCIENCES ET GÉNIE S.E.C. (CA) | 2018-06-12 | — | — | US | disclosed |
| EP-2440533-B1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA SCIENCES ET GÉNIE S E C (CA) | 2015-09-23 | — | — | EP | disclosed |
| US-20150150890-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | UNIVERSITE DE SHERBROOKE (CA) | 2015-06-04 | — | — | US | disclosed |
| US-20150150890-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | UNIVERSITE DE SHERBROOKE (CA) | 2015-06-04 | — | — | US | disclosed |
| US-20120122819-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA - SCIENCES ET GENIE S.E.C. (CA) | 2012-05-17 | — | — | US | disclosed |
| US-20120122819-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA - SCIENCES ET GENIE S.E.C. (CA) | 2012-05-17 | — | — | US | disclosed |
| WO-2010142027-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | SOCPRA - SCIENCES ET GENIE S. E. C. (CA) | 2010-12-16 | — | — | WO | disclosed |
| EP-0636372-B1 | Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives | ICN PHARMACEUTICALS (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0348446-B1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | UNIV BRIGHAM YOUNG (US) | 1995-08-09 | — | — | EP | disclosed |
| EP-0636372-A1 | Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives | BRIGHAM YOUNG UNIVERSITY (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0348446-A4 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | — | 1991-09-25 | — | — | EP | disclosed |
| US-5041426-A | Viricides, antitumor agents | BRIGHAM YOUNG UNIVERSITY (US) | 1991-08-20 | — | — | US | disclosed |
| EP-0348446-A1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES. | UNIV BRIGHAM YOUNG (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4880784-A | ANTITUMOR AGENTS | BRIGHAM YOUNG UNIVERSITY (US) | 1989-11-14 | — | — | US | disclosed |
| WO-1989005649-A1 | ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES | BRIGHAM YOUNG UNIVERSITY (US) | 1989-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150890-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | GDA, RNMT, GNPDA1 | PNP 618/4885DYRK1A 3837/4885AURKA 4450/4885 |
| US-20120122819-A1 | GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS | GDA, RNMT, GNPDA1 | PNP 618/4885DYRK1A 3837/4885AURKA 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.