Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ENGASE | Q8NFI3 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.41 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8860695 | 0.86 | MAPT (0.36) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL8670315 | 0.84 | MAPT (0.33) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL8668979 | 0.84 | MEN1 (0.36) | MAPTNPC1RAB9ATSHRKMT2A | |
| SCHEMBL8438828 | 0.83 | KMT2A (0.41) | MAPTNPC1RAB9ACYP2C9TSHR | |
| SCHEMBL8672636 | 0.80 | SMN1; SMN2 (0.37) | MAPTNPC1RAB9ACYP2C9TSHR | |
| SCHEMBL8860680 | 0.78 | KDM4E (0.31) | MAPTKDM4E | |
| SCHEMBL8672844 | 0.78 | MAPT (0.30) | MAPT | |
| SCHEMBL8442772 | 0.78 | HTR1D (0.41) | TSHRKMT2ALMNAKDM4EGAA | |
| SCHEMBL1559770 | 0.77 | MAPT (0.50) | MAPTNPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1559910 | 0.77 | MAPT (0.50) | MAPTNPC1RAB9ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948789-A | ASYMMETRIC OXIDATION OF A PRO-CHIRAL SULPHIDE TO THE SINGLE ENANTIOMERS OR AN ENANTIOMERICALLY ENRICHED FORM OF THE CORRESPONDING SULPHOXIDE. OPTICALLY PURE SUBSTITUTED 2-(2-PYRIDINYLMETHYL-SULPHINYL)-1H-BENZIMIDAZOLES. | ASTRA AKTIEBOLAG (SE) | 1999-09-07 | — | — | US | disclosed |
| US-5929244-A | TREATING AN ENANTIOMERICALLY ENRICHED PREPARATION OF THE COMPOUND IN FAVOUR OF ITS (+) OR (-)-ENANTIOMER AT ROOM TEMPERATURE OR BELOW WITH A SOLVENT SELECTED FROM KETONES, ESTERS, ALCOHOL, NITRILES, HYROCARBONS, ETHERS, AMIDES | ASTRA AKTIEBOLAG (SE) | 1999-07-27 | — | — | US | disclosed |
| US-5731002-A | ANTISECRETORY | ASTRA AKTIEBOLAG (SE) | 1998-03-24 | — | — | US | disclosed |