Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 9/20 | 0.55 |
| ▸ | FNTB | P49356 | 9/20 | 0.55 |
| ▸ | PGGT1B | P53609 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6003187 | 1.00 | FNTA (0.55) | FNTAFNTBPGGT1BLMNASMN1; SMN2 | |
| SCHEMBL5298259 | 0.92 | FNTA (0.51) | FNTAFNTBPGGT1BLMNASMN1; SMN2 | |
| SCHEMBL8434426 | 0.92 | FNTA (0.51) | FNTAFNTBPGGT1BLMNASMN1; SMN2 | |
| SCHEMBL5285086 | 0.91 | MAPK1 (0.48) | FNTAFNTBPGGT1BLMNASMN1; SMN2 | |
| SCHEMBL7513048 | 0.91 | MAPK1 (0.48) | FNTAFNTBPGGT1BLMNASMN1; SMN2 | |
| SCHEMBL8104389 | 0.91 | ALDH1A1 (0.57) | FNTAFNTBPGGT1BALDH1A1CYP11B1 | |
| SCHEMBL8103587 | 0.91 | ALDH1A1 (0.57) | FNTAFNTBPGGT1BALDH1A1CYP11B1 | |
| SCHEMBL8423622 | 0.91 | ALDH1A1 (0.57) | FNTAFNTBPGGT1BALDH1A1CYP11B1 | |
| SCHEMBL8097870 | 0.90 | CYP11B1 (0.53) | FNTAFNTBPGGT1BALDH1A1KMT2A | |
| SCHEMBL8534851 | 0.90 | CYP11B1 (0.53) | FNTAFNTBPGGT1BALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862435-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | claimed |
| EP-0862435-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | claimed |
| WO-1997018813-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-05-29 | — | — | WO | claimed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |