Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 5/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8437447 | 1.00 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8433464 | 0.99 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8438272 | 0.83 | TRPV1 (0.36) | CYP1A2CASP3SENP7SENP8SENP6 | |
| Hydrochloric Acid SCHEMBL8438263 | 0.83 | TRPV1 (0.36) | CYP1A2CASP3SENP7SENP8SENP6 | |
| SCHEMBL8433800 | 0.75 | NR1H4 (0.45) | RAB9ANPC1SMN1; SMN2L3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL8437871 | 0.74 | NR1H4 (0.44) | RAB9ANPC1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL8438345 | 0.73 | ATM (0.45) | CYP1A2 | |
| Hydrochloric Acid SCHEMBL8434597 | 0.71 | IDH1 (0.41) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8437843 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL8435794 | 0.68 | L3MBTL1 (0.46) | RAB9ANPC1SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |