Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 3/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869581 | 0.81 | ANPEP (0.48) | ANPEPNPSR1BIRC2ALDH1A1 | |
| SCHEMBL8256405 | 0.81 | ANPEP (0.48) | ANPEPNPSR1BIRC2ALDH1A1 | |
| SCHEMBL8431357 | 0.81 | TAS1R3 (0.42) | TAS1R3TAS1R1ANPEPNPC1RAB9A | |
| SCHEMBL8437201 | 0.80 | IL1RN (0.50) | TAS1R3TAS1R1ANPEPSMN1; SMN2NPSR1 | |
| SCHEMBL8437493 | 0.74 | ACE2 (0.40) | TAS1R3TAS1R1ANPEPSMN1; SMN2 | |
| SCHEMBL8256593 | 0.74 | P2RY12 (0.45) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL8429973 | 0.74 | P2RY12 (0.45) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL8440620 | 0.73 | FOLH1 (0.48) | TAS1R3TAS1R1NPC1RAB9AHPGD | |
| SCHEMBL8437797 | 0.70 | ACE2 (0.44) | TAS1R3TAS1R1ANPEPL3MBTL1ALDH1A1 | |
| SCHEMBL8255240 | 0.70 | P2RY12 (0.44) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | TAS1R3 4635/4885TAS1R1 4625/4885ANPEP 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.