Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1RN | P18510 | 6/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 5/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPY4R | P50391 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440620 | 0.93 | FOLH1 (0.48) | IL1RNERAP2ERAP1FOLH1TAS1R3 | |
| SCHEMBL8248870 | 0.82 | ANPEP (0.55) | IL1RNERAP2ERAP1FOLH1TSHR | |
| SCHEMBL8008631 | 0.82 | NPSR1 (0.53) | IL1RNERAP2ERAP1TSHRCNR1 | |
| SCHEMBL6826832 | 0.82 | NPSR1 (0.53) | IL1RNERAP2ERAP1TSHRCNR1 | |
| SCHEMBL1721283 | 0.82 | NPSR1 (0.53) | IL1RNERAP2ERAP1TSHRCNR1 | |
| SCHEMBL8436685 | 0.80 | HPGD (0.42) | IL1RNERAP2ERAP1FOLH1LMNA | |
| SCHEMBL8437490 | 0.80 | TAS1R3 (0.42) | TAS1R3TAS1R1ANPEPNPSR1SMN1; SMN2 | |
| SCHEMBL9848012 | 0.78 | ESR1 (0.48) | IL1RNERAP2ERAP1TSHRCNR1 | |
| SCHEMBL3055258 | 0.78 | TACR1 (0.50) | TSHRCNR1CNR2ESR1ESR2 | |
| SCHEMBL3055256 | 0.78 | TACR1 (0.50) | TSHRCNR1CNR2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | IL1RN 1603/4885ERAP2 33/4885ERAP1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.