Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.58 |
| ▸ | RARA | P10276 | 4/20 | 0.54 |
| ▸ | RARB | P10826 | 4/20 | 0.54 |
| ▸ | RARG | P13631 | 4/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442921 | 0.93 | RARG (0.55) | PTPN11PTPN1PTPN6RARARARB | |
| SCHEMBL8656079 | 0.84 | RARG (0.58) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL8688418 | 0.84 | RARA (0.47) | PTPN11RARARARBRARGRXRA | |
| SCHEMBL8461877 | 0.81 | RXRA (0.65) | PTPN11RARARARBRARGS1PR3 | |
| SCHEMBL27245972 | 0.77 | PTPN11 (1.00) | PTPN11PTPN1PTPN6RARBS1PR3 | |
| SCHEMBL25788077 | 0.76 | PTPN11 (0.67) | PTPN11PTPN1PTPN6S1PR3 | |
| SCHEMBL9417624 | 0.76 | PTPN11 (0.67) | PTPN11PTPN1PTPN6S1PR3 | |
| SCHEMBL8693295 | 0.76 | RARG (0.50) | RARARARBRARGRXRA | |
| SCHEMBL27288709 | 0.75 | PTPN11 (0.74) | PTPN11PTPN1PTPN6RARARARB | |
| SCHEMBL6870756 | 0.75 | PTPN11 (0.52) | PTPN11PTPN1PTPN6RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | claimed |
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | disclosed |