Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8437496 | 0.99 | TSHR (0.48) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| SCHEMBL8433423 | 0.81 | TDP1 (0.45) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL8434788 | 0.80 | TDP1 (0.44) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| SCHEMBL8438546 | 0.80 | SMN1; SMN2 (0.47) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL8437558 | 0.79 | SMN1; SMN2 (0.46) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| SCHEMBL8432986 | 0.78 | TAAR1 (0.46) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL8435756 | 0.78 | TAAR1 (0.45) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| SCHEMBL8434782 | 0.76 | CA1 (0.42) | TSHRMAPK1LMNAL3MBTL1TDP1 | |
| SCHEMBL8433601 | 0.76 | ALDH1A1 (0.35) | LMNAL3MBTL1KDM4EMAPTALDH1A1 | |
| SCHEMBL8435676 | 0.74 | L3MBTL1 (0.45) | MAPK1LMNAL3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874585-A | TREATMENT AND/OR PREVENTION OF ELASTASE-MEDIATED PROBLEMS SUCH AS ARTHRITIS, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, DERMATITIS, PSORIASIS, CYSTIC FIBROSIS, CHRONIC BRONCHITIS, ALZHEIMER'S DISEASE | CORTECH, INC. (US) | 1999-02-23 | — | — | US | disclosed |