Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796162 | 0.82 | EGFR (0.63) | DHFREGFRHPGDSNQO1PDGFRB | |
| SCHEMBL1161417 | 0.79 | EGFR (0.59) | EGFRNQO1PDGFRBPDGFRAMAPT | |
| SCHEMBL8434822 | 0.76 | PDGFRB (0.42) | DHFREGFRPDGFRBPDGFRAMAPT | |
| SCHEMBL27878442 | 0.75 | AR (0.49) | DHFRHAO1AAK1MAPTHTT | |
| SCHEMBL7803054 | 0.75 | DHFR (0.42) | DHFREGFRMAPTHTT | |
| SCHEMBL7796228 | 0.72 | CSF1R (0.42) | DHFREGFRPDGFRBPDGFRAHAO1 | |
| SCHEMBL27878604 | 0.71 | APP (0.66) | DHFRMAPT | |
| SCHEMBL12361591 | 0.70 | EGFR (0.59) | EGFRHPGDSPDGFRBPDGFRA | |
| SCHEMBL7804802 | 0.70 | MTNR1A (0.44) | DHFREGFRMAPT | |
| SCHEMBL7803061 | 0.70 | IP6K1 (0.58) | DHFRHAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990116-A | USE IN PREVENTION OR TREATMENT OF INFLAMMATORY AND PROLIFERATIVE SKIN DISEASES AND CANCER; COMPOUNDS SUCH AS 6-(2-(2,5-DIMETHOXYPHENYL)ETHYL)-4-ETHYL-QUINAZOLINE | NOVARTIS AG (CH) | 1999-11-23 | — | — | US | disclosed |