SCHEMBL8438859

SCHEMBL8438859

FC(F)(F)[CH]c1cc(Cl)cc(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.47
TSHR P16473 1/20 0.42
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15741471 0.86 AHR (0.37) AHR
SCHEMBL15741495 0.84 AHR (0.48) AHRTSHRCYP3A4
SCHEMBL14845143 0.84 AHR (0.36) AHR
SCHEMBL21411402 0.77 CHRM5 (0.52) TSHR
SCHEMBL854920 0.75 AHR (0.53) AHRTSHRTP53CYP3A4
SCHEMBL8440877 0.75 HCAR2 (0.35) AHR
SCHEMBL8046808 0.74 HSD17B10 (0.46) AHR
SCHEMBL15541156 0.71 TSHR (0.53) AHRTSHRTP53CYP3A4
SCHEMBL16959911 0.70 TRPA1 (0.41) AHR
SCHEMBL11042641 0.69 TSHR (0.50) AHRTSHRTP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2922831-A1 PESTICIDAL COMPOUNDS BASED ON ARYLTHIOSULFONAMIDE DERIVATIVES Syngenta Participations AG (CH) 2015-09-30 EP disclosed
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed
WO-2014079937-A1 PESTICIDAL COMPOUNDS BASED ON ARYLTHIOSULFONAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2014-05-30 WO disclosed
US-5968947-A INSECTICIDES, ACARICIDES, NEMATOCIDES ZENECA LIMITED (GB) 1999-10-19 US disclosed