Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.52 |
| ▸ | F2 | P00734 | 4/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442698 | 0.85 | F10 (0.49) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8908070 | 0.83 | F10 (0.57) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8439295 | 0.77 | FOLH1 (0.38) | — | |
| SCHEMBL8909339 | 0.76 | F10 (0.50) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8696206 | 0.75 | F10 (0.54) | F10F2 | |
| SCHEMBL8441533 | 0.72 | F10 (0.64) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8442920 | 0.72 | F10 (0.57) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7364511 | 0.72 | F10 (0.57) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6432819 | 0.71 | F10 (0.84) | F10F2 | |
| SCHEMBL8442914 | 0.70 | F10 (0.52) | F10F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863914-A | ADMINISTERING TO HUMAN N,N-DIMETHYLBENZENE OR N,N-DIMETHYLNAPHTHALENE-CYCLIC UREA DERIVATIVE TO TREAT A DISEASE-STATE CAUSED BY INHIBITION OF FACTOR XA | MOHAN RAJU (US) | 1999-01-26 | — | — | US | disclosed |
| US-5859005-A | INHIBITORS OF THROMBIN AND FACTOR XA | BERLEX LABORATORIES, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5731308-A | N,N-di(aryl) cyclic urea derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5731311-A | N,N-di(aryl) cyclic urea derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5728697-A | INHIBITORS OF FACTOR X | BERLEX LABORATORIES, INC. (US) | 1998-03-17 | — | — | US | disclosed |
| US-5726173-A | ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5726198-A | FOR INHIBITING COAGULATION ENZYMES | BERLEX LABORATORIES, INC. (US) | 1998-03-10 | — | — | US | disclosed |