Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PYGM | P11217 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439132 | 0.89 | KDM4E (0.43) | KDM4EPOLBMEN1KMT2A | |
| SCHEMBL8441401 | 0.89 | L3MBTL1 (0.41) | KDM4EPOLB | |
| SCHEMBL8441933 | 0.88 | CASP1 (0.43) | KDM4EPOLBLMNA | |
| SCHEMBL8441904 | 0.87 | PTGER4 (0.40) | KDM4EPOLBSLC1A5 | |
| SCHEMBL8440073 | 0.87 | P2RX4 (0.43) | LMNAP2RX4 | |
| SCHEMBL8441913 | 0.85 | KDM4E (0.58) | KDM4EPOLBLMNAPYGMMEN1 | |
| SCHEMBL8441432 | 0.85 | MEN1 (0.43) | KDM4EPOLBLMNAMEN1KMT2A | |
| SCHEMBL8440212 | 0.85 | — | — | |
| SCHEMBL8441118 | 0.84 | KCNQ3 (0.44) | KDM4ELMNA | |
| SCHEMBL8438239 | 0.83 | HTT (0.54) | KDM4EPOLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708088-B1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0708088-A1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1996-04-24 | — | — | EP | disclosed |