Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438412 | 0.88 | MEN1 (0.40) | HTTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL8441432 | 0.87 | MEN1 (0.43) | HTTALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL8443162 | 0.86 | CXCL8 (0.47) | HTTALDH1A1HPGDLMNANPSR1 | |
| SCHEMBL8443014 | 0.86 | CXCL8 (0.46) | HTT | |
| SCHEMBL8441401 | 0.86 | L3MBTL1 (0.41) | ALDH1A1KDM4ENPSR1SMN1; SMN2POLB | |
| SCHEMBL8441923 | 0.85 | — | — | |
| SCHEMBL8442155 | 0.85 | HTT (0.56) | HTTALDH1A1KDM4EHPGDIDO1 | |
| SCHEMBL8439132 | 0.84 | KDM4E (0.43) | ALDH1A1KDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL8439615 | 0.83 | IDO1 (0.41) | ALDH1A1IDO1KMT2A | |
| SCHEMBL8439862 | 0.83 | KDM4E (0.55) | KDM4ELMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708088-B1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GMBH (DE) | 1999-03-24 | — | — | EP | disclosed |
| US-5700839-A | ANTIARRYTHMIA AGENTS; ACT AS INHIBITORS OF THE CELLULAR NA+/H+ ANTIPORTER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0708088-A1 | Alkyl-5-methylsulphonyl-benzoyl-guanidine derivatives | MERCK PATENT GmbH (DE) | 1996-04-24 | — | — | EP | disclosed |