Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.54 |
| ▸ | RXRB | P28702 | 2/20 | 0.54 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | DDT | P30046 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440446 | 0.82 | CA12 (0.47) | — | |
| SCHEMBL8443910 | 0.81 | CYP2A6 (0.58) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL6254589 | 0.78 | RXRA (0.59) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL2371293 | 0.78 | KMO (0.61) | RXRARXRBKMOFOLH1FABP4 | |
| SCHEMBL5841701 | 0.77 | RXRA (0.57) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL29386545 | 0.77 | KMO (0.69) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL16749639 | 0.77 | KMO (0.69) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL442436 | 0.75 | SRD5A2 (0.62) | RXRARXRBKMOMAP4K4 | |
| SCHEMBL2213546 | 0.75 | KMO (0.73) | RXRARXRBKMODDTFOLH1 | |
| SCHEMBL30259065 | 0.75 | KMO (0.73) | RXRARXRBKMODDTFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1070173-C | Benzoylguanidine derivatives as medicaments | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-08-29 | — | — | CN | disclosed |
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| CN-1158606-A | Benzoylguanidine derivatives as medicaments | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-09-03 | — | — | CN | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |