Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439771 | 0.96 | GRIN2B (0.52) | GRIN2BACHECRBNHTR1ADRD4 | |
| SCHEMBL8302305 | 0.90 | GRIN2B (0.52) | GRIN2BACHEHTR1AHTR2AHTR7 | |
| SCHEMBL7328182 | 0.86 | GRIN2B (0.62) | GRIN2BACHECRBNHTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL11255645 | 0.85 | GRIN2B (0.57) | GRIN2BCRBNHTR1ADRD4HTR2A | |
| SCHEMBL2237118 | 0.82 | SMYD3 (0.51) | GRIN2BCRBNHTR1ADRD4HTR2A | |
| SCHEMBL7344494 | 0.81 | GRIN2B (0.57) | GRIN2BCRBNHTR1ADRD4HTR2A | |
| SCHEMBL8543583 | 0.80 | ACHE (0.60) | GRIN2BACHE | |
| Hydrochloric Acid SCHEMBL10838416 | 0.79 | GRIN2B (0.55) | GRIN2BCRBNHTR1ADRD4HTR2A | |
| Hydrochloric Acid SCHEMBL7349822 | 0.79 | GRIN2B (0.55) | GRIN2BCRBNHTR1ADRD4HTR2A | |
| SCHEMBL5470505 | 0.78 | GRIN2B (0.53) | GRIN2BCRBNHTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888340-A1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | Abbott Laboratories (US) | 1999-01-07 | — | — | EP | claimed |
| WO-1997030046-A1 | 4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | ABBOTT LABORATORIES (US) | 1997-08-21 | — | — | WO | claimed |
| EP-0848707-B1 | 4-(CYCLOALKYL)PIPERIDINES AND 4-(CYCLOALKYLALKYL)-PIPERIDINES DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL APPLICATIONS THEREOF | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |