Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 10/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440778 | 0.86 | GRIN2B (0.53) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL8543583 | 0.84 | ACHE (0.60) | GRIN2BACHE | |
| SCHEMBL8439771 | 0.84 | GRIN2B (0.52) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL466903 | 0.82 | DRD2 (0.57) | ACHEBCHEHTR1ADRD4HTR2A | |
| SCHEMBL8548011 | 0.81 | GRIN2B (0.62) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL8542972 | 0.80 | GRIN2B (0.60) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL466863 | 0.80 | GRIN2B (0.61) | GRIN2BACHEBCHEHTR1ADRD4 | |
| SCHEMBL10835747 | 0.79 | HTR1A (0.63) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL16608472 | 0.78 | GRIN2B (0.73) | GRIN2BACHEHTR1ADRD4HTR2A | |
| SCHEMBL8546120 | 0.78 | GRIN2B (0.58) | GRIN2BACHEHTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5212181-A | 1-(3,4-dihydro-2-oxo-1H-quinolin-6-yl)-2-[4-(2-phenylethyl)piperidin-1-yl]et[4-(2-phenylethyl)piperidin-1-yl]ethanone, to their preparation and to their therapeutic application | SYNTHELABO (FR) | 1993-05-18 | — | — | US | claimed |
| EP-0481853-A1 | 1-(3,4-Dihydro-2-oxo-1H-quinoline-6-yl)-2-[4-(2-phenylethyl)-piperidin-1-yl]ethanol and -ethane, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1992-04-22 | — | — | EP | claimed |
| US-5212181-A | 1-(3,4-dihydro-2-oxo-1H-quinolin-6-yl)-2-[4-(2-phenylethyl)piperidin-1-yl]et[4-(2-phenylethyl)piperidin-1-yl]ethanone, to their preparation and to their therapeutic application | SYNTHELABO (FR) | 1993-05-18 | — | — | US | disclosed |
| EP-0481853-A1 | 1-(3,4-Dihydro-2-oxo-1H-quinoline-6-yl)-2-[4-(2-phenylethyl)-piperidin-1-yl]ethanol and -ethane, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1992-04-22 | — | — | EP | disclosed |