SCHEMBL8440937

SCHEMBL8440937

Clc1ccc(OCC[C@@H]2CCCN2)cn1

nearest known ligand 0.75

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 4/20 0.75
CHRNB2 P17787 7/20 0.59
CHRNA4 P43681 7/20 0.59
CHRNB4 P30926 2/20 0.59
CHRNA7 P36544 1/20 0.59
LTA4H P09960 1/20 0.47
CYP2D6 P10635 3/20 0.46
SSTR2 P30874 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7409148 0.99 CHRNA3 (0.73) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
SCHEMBL7417656 0.90 CHRNB2 (0.73) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
SCHEMBL905233 0.86 CHRNA3 (1.00) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
SCHEMBL8440116 0.86 CHRNA3 (1.00) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
Hydrochloric Acid SCHEMBL8437569 0.84 CHRNA3 (0.97) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
Hydrochloric Acid SCHEMBL8435785 0.84 CHRNA3 (0.97) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
SCHEMBL11447734 0.82 LTA4H (0.67) CHRNA3LTA4H
SCHEMBL8438067 0.78 CHRNA3 (0.67) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7
SCHEMBL11448671 0.78 LTA4H (0.68) LTA4HSSTR2
SCHEMBL8436385 0.78 CHRNB2 (0.59) CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP claimed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO claimed
US-5914328-A CONTROL DOPAMINE RELEASE, ACTIVATE CHOLINERGIC CHANNELS ABBOTT LABORATORIES (US) 1999-06-22 US disclosed
EP-0846114-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 1998-06-10 EP disclosed
WO-1996040682-A1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1996-12-19 WO disclosed