Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 5/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024844 | 0.89 | ADRB2 (0.55) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL19024934 | 0.86 | ADRB2 (0.57) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL28226601 | 0.84 | ADRB2 (0.61) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL31657295 | 0.80 | ADRB2 (0.57) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL19024897 | 0.80 | TDP1 (0.58) | ADRB2ADRB1ADRB3SMN1; SMN2FAAH | |
| SCHEMBL27770588 | 0.80 | ADRB2 (0.57) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL23545819 | 0.80 | LPAR1 (0.60) | ADRB2ADRB1ADRB3FAAHLPAR1 | |
| SCHEMBL9463643 | 0.79 | LPAR1 (0.71) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL1889682 | 0.79 | SMN1; SMN2 (0.53) | ADRB2ADRB1ADRB3HDAC3HDAC1 | |
| SCHEMBL29875826 | 0.78 | TDP1 (0.60) | ADRB2ADRB1ADRB3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869786-A4 | PHARMACEUTICAL COMPOUNDS | LILLY CO ELI (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0869786-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023211-A1 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-07-03 | — | — | WO | disclosed |