Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443669 | 0.93 | HMOX1 (0.40) | HMOX1TRPA1MAPK1SMN1; SMN2KEAP1 | |
| SCHEMBL8094772 | 0.92 | HMOX1 (0.39) | HMOX1HDAC3LMNAMAPTTDP1 | |
| SCHEMBL8104046 | 0.91 | HMOX1 (0.38) | HMOX1TRPA1MAPK1SMN1; SMN2KEAP1 | |
| SCHEMBL8110056 | 0.90 | HPGD (0.41) | HMOX1HDAC3EPHX2LMNAMAPT | |
| SCHEMBL8772387 | 0.88 | HMOX1 (0.40) | HMOX1TRPA1SMN1; SMN2EPHX2KEAP1 | |
| SCHEMBL8102560 | 0.84 | HMOX1 (0.40) | HMOX1ALOX5TRPA1SMN1; SMN2KEAP1 | |
| SCHEMBL8772384 | 0.84 | MAPT (0.42) | HDAC1HDAC2ALOX5EPHX2MAPT | |
| SCHEMBL8772382 | 0.83 | HMOX1 (0.40) | HMOX1TRPA1MAPK1SMN1; SMN2KEAP1 | |
| SCHEMBL8443497 | 0.83 | HMOX1 (0.40) | HMOX1TRPA1MAPK1SMN1; SMN2KEAP1 | |
| SCHEMBL8442244 | 0.83 | HMOX1 (0.40) | HMOX1TRPA1MAPK1SMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |