Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772512 | 0.93 | PLAAT3 (0.40) | POLBNPC1 | |
| SCHEMBL8772384 | 0.91 | MAPT (0.42) | EPHX2 | |
| SCHEMBL8440303 | 0.91 | TP53 (0.45) | POLBTDP1NPC1ALDH1A1L3MBTL1 | |
| SCHEMBL8443669 | 0.90 | HMOX1 (0.40) | HMOX1POLBKEAP1TDP1NPC1 | |
| SCHEMBL8104046 | 0.88 | HMOX1 (0.38) | HMOX1POLBKEAP1TDP1NPC1 | |
| SCHEMBL8442702 | 0.88 | HMOX1 (0.38) | HMOX1KEAP1TDP1NPC1TRPA1 | |
| SCHEMBL8102560 | 0.86 | HMOX1 (0.40) | HMOX1POLBKEAP1TDP1NPC1 | |
| SCHEMBL8440093 | 0.86 | ITGB1 (0.39) | POLBALDH1A1L3MBTL1HPGD | |
| SCHEMBL8442244 | 0.85 | HMOX1 (0.40) | HMOX1POLBKEAP1TDP1NPC1 | |
| SCHEMBL8443497 | 0.85 | HMOX1 (0.40) | HMOX1POLBKEAP1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |