Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 5/20 | 0.40 |
| ▸ | FAAH | O00519 | 5/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772387 | 0.91 | HMOX1 (0.40) | EPHX2 | |
| SCHEMBL8104210 | 0.88 | MAPT (0.43) | MAPTRXFP1NAAAFAAHPTGER4 | |
| SCHEMBL8104122 | 0.88 | MAPT (0.43) | MAPTRXFP1NAAAFAAHPTGER4 | |
| SCHEMBL8440062 | 0.87 | HDAC1 (0.43) | MAPTRXFP1NAAAEPHX1ALOX5 | |
| SCHEMBL8772512 | 0.85 | PLAAT3 (0.40) | — | |
| SCHEMBL8442702 | 0.84 | HMOX1 (0.38) | MAPTRXFP1NAAAALOX5HDAC1 | |
| SCHEMBL8442084 | 0.84 | TRPV1 (0.48) | EPHX1EPHX2 | |
| SCHEMBL8438732 | 0.84 | TRPV1 (0.48) | EPHX1EPHX2 | |
| SCHEMBL27495125 | 0.84 | TRPV1 (0.48) | EPHX1EPHX2 | |
| SCHEMBL8772503 | 0.84 | TRPV1 (0.48) | EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |